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Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: mechanistic studies with 18O.
/0 Comments/in Publications /by syn-adminNiles JC, Wishnok JS, Tannenbaum SR. 2004. Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: mechanistic studies with 18O. Chem Res Toxicol. 17(11):1510-9. Google Scholar PubMed
Mass spectrometric identification of 4-hydroxy-2,5-dioxo-imidazolidine-4-carboxylic acid during oxidation of 8-oxoguanosine by peroxynitrite and KHSO5/CoCl2.
/0 Comments/in Publications /by syn-adminNiles JC, Wishnok JS, Tannenbaum SR. 2004. Mass spectrometric identification of 4-hydroxy-2,5-dioxo-imidazolidine-4-carboxylic acid during oxidation of 8-oxoguanosine by peroxynitrite and KHSO5/CoCl2. Chem Res Toxicol. 17(11):1501-9. Google Scholar PubMed
Peroxynitrite reacts with 8-nitropurines to yield 8-oxopurines.
/0 Comments/in Publications /by syn-adminLee JM, Niles JC, Wishnok JS, Tannenbaum SR. 2002. Peroxynitrite reacts with 8-nitropurines to yield 8-oxopurines. Chem Res Toxicol. 15(1):7-14. Google Scholar PubMed
Spiroiminodihydantoin is the major product of the 8-oxo-7,8-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue.
/0 Comments/in Publications /by syn-adminNiles JC, Wishnok JS, Tannenbaum SR. 2001. Spiroiminodihydantoin is the major product of the 8-oxo-7,8-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue. Org Lett. 3(7):963-6. Google Scholar PubMed
A novel nitration product formed during the reaction of peroxynitrite with 2′,3′,5′-tri-O-acetyl-7,8-dihydro-8-oxoguanosine: N-nitro-N’-[1-(2,3,5-tri-O-acetyl-beta-D-erythro-pentofuranosyl)- 2, 4-dioxoimidazolidin-5-ylidene]guanidine.
/0 Comments/in Publications /by syn-adminDNA damage in deoxynucleosides and oligonucleotides treated with peroxynitrite.
/0 Comments/in Publications /by syn-adminPeroxynitrite-induced reactions of synthetic oligonucleotides containing 8-oxoguanine.
/0 Comments/in Publications /by syn-adminTretyakova NY, Niles JC, Burney S, Wishnok JS, Tannenbaum SR. 1999. Peroxynitrite-induced reactions of synthetic oligonucleotides containing 8-oxoguanine. Chem Res Toxicol. 12(5):459-66. Google Scholar PubMed
The chemistry of DNA damage from nitric oxide and peroxynitrite.
/0 Comments/in Publications /by syn-adminBurney S, Caulfield JL, Niles JC, Wishnok JS, Tannenbaum SR. 1999. The chemistry of DNA damage from nitric oxide and peroxynitrite. Mutat Res. 424(1-2):37-49. Google Scholar PubMed