Synthetic Biology Center

Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation.

March 1, 2006/0 Comments/in Publications /by syn-admin

Niles JC, Wishnok JS, Tannenbaum SR. 2006. Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation. Nitric Oxide. 14(2):109-21. Google Scholar PubMed

Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations.

January 1, 2005/0 Comments/in Publications /by syn-admin

Henderson PT, Neeley WL, Delaney JC, Gu F, Niles JC, Hah SSoo, Tannenbaum SR, Essigmann JM. 2005. Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations. Chem Res Toxicol. 18(1):12-8. Google Scholar PubMed

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Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation.

Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations.

Peroxynitrite reacts with 8-nitropurines to yield 8-oxopurines.

DNA damage in deoxynucleosides and oligonucleotides treated with peroxynitrite.

Peroxynitrite-induced reactions of synthetic oligonucleotides containing 8-oxoguanine.

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