Posts

Crystal structure of Cas9 in complex with guide RNA and target DNA.

Nishimasu H, F Ran A, Hsu PD, Konermann S, Shehata SI, Dohmae N, Ishitani R, Zhang F, Nureki O.  2014.  Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell. 156(5):935-49. Google Scholar PubMed

A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.

Aakre CD, Phung TN, Huang D, Laub MT.  2013.  A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp. Mol Cell. 52(5):617-28. Google Scholar PubMed

High-resolution mapping of the spatial organization of a bacterial chromosome.

Le TBK, Imakaev MV, Mirny LA, Laub MT.  2013.  High-resolution mapping of the spatial organization of a bacterial chromosome. Science. 342(6159):731-4. Google Scholar PubMed

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.

Bikard D, Jiang W, Samai P, Hochschild A, Zhang F, Marraffini LA.  2013.  Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res. 41(15):7429-37. Google Scholar PubMed

Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA.

Jonas K, Liu J, Chien P, Laub MT.  2013.  Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA. Cell. 154(3):623-36. Google Scholar PubMedveroxybd.com

Towards a whole-cell modeling approach for synthetic biology.

Purcell O, Jain B, Karr JR, Covert MW, Lu TK.  2013.  Towards a whole-cell modeling approach for synthetic biology. Chaos. 23(2):025112. Google Scholar PubMed

Determinants of specificity in two-component signal transduction.

Podgornaia AI, Laub MT.  2013.  Determinants of specificity in two-component signal transduction. Curr Opin Microbiol. 16(2):156-62. Google Scholar PubMedsports74.ru

Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in Caulobacter crescentus.

Gora KG, Cantin A, Wohlever M, Joshi KK, Perchuk BS, Chien P, Laub MT.  2013.  Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in Caulobacter crescentus. Mol Microbiol. 87(6):1277-89. Google Scholar PubMed

RNA-guided editing of bacterial genomes using CRISPR-Cas systems.

Jiang W, Bikard D, Cox D, Zhang F, Marraffini LA.  2013.  RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol. 31(3):233-9. Google Scholar PubMed