Posts

Synthesis and patterning of tunable multiscale materials with engineered cells

Chen AY, Deng Z, Billings AN, Seker UOS, Lu MY, Citorik RJ, Zakeri B, Lu TK.  2014.  Synthesis and patterning of tunable multiscale materials with engineered cells. Nat Mater. 13(5):515-23. Google Scholar PubMed

A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.

Aakre CD, Phung TN, Huang D, Laub MT.  2013.  A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp. Mol Cell. 52(5):617-28. Google Scholar PubMed

Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling.

Podgornaia AI, Casino P, Marina A, Laub MT.  2013.  Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling. Structure. 21(9):1636-47. Google Scholar PubMed

DNA targeting specificity of RNA-guided Cas9 nucleases.

Hsu PD, Scott DA, Weinstein JA, F Ran A, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O et al..  2013.  DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol. 31(9):827-32. Google Scholar PubMed

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.

Bikard D, Jiang W, Samai P, Hochschild A, Zhang F, Marraffini LA.  2013.  Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res. 41(15):7429-37. Google Scholar PubMed

Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA.

Jonas K, Liu J, Chien P, Laub MT.  2013.  Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA. Cell. 154(3):623-36. Google Scholar PubMedveroxybd.com

Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.

Ashenberg O, Keating AE, Laub MT.  2013.  Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans. J Mol Biol. 425(7):1198-209. Google Scholar PubMed

Determinants of specificity in two-component signal transduction.

Podgornaia AI, Laub MT.  2013.  Determinants of specificity in two-component signal transduction. Curr Opin Microbiol. 16(2):156-62. Google Scholar PubMedsports74.ru

Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity.

Capra EJ, Perchuk BS, Ashenberg O, Seid CA, Snow HR, Skerker JM, Laub MT.  2012.  Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity. Mol Microbiol. 86(6):1393-403. Google Scholar PubMed

Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.

Capra EJ, Perchuk BS, Skerker JM, Laub MT.  2012.  Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families. Cell. 150(1):222-32. Google Scholar PubMed