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Development and applications of CRISPR-Cas9 for genome engineering

Hsu PD, Lander ES, Zhang F.  2014.  Development and applications of CRISPR-Cas9 for genome engineering. Cell. 157(6):1262-78. Google Scholar PubMed

Synthetic biology: How best to build a cell.

Collins JJ, Maxon M, Ellington A, Fussenegger M, Weiss R, Sauro H.  2014.  Synthetic biology: How best to build a cell. Nature. 509(7499):155-7.  Google Scholar PubMed

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.

F Ran A, Hsu PD, Lin C-Y, Gootenberg JS, Konermann S, Trevino AE, Scott DA, Inoue A, Matoba S, Zhang Y et al..  2013.  Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell. 154(6):1380-9. Google Scholar PubMed

Optical control of mammalian endogenous transcription and epigenetic states.

Konermann S, Brigham MD, Trevino AE, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F.  2013.  Optical control of mammalian endogenous transcription and epigenetic states. Nature. 500(7463):472-6. Google Scholar PubMed. Google Scholar PubMed

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R.  2013.  One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell. 153(4):910-8. Google Scholar PubMed

Multiplex genome engineering using CRISPR/Cas systems.

Cong L, F Ran A, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA et al..  2013.  Multiplex genome engineering using CRISPR/Cas systems. Science. 339(6121):819-23. Google Scholar PubMed

Dissecting neural function using targeted genome engineering technologies.

Hsu PD, Zhang F.  2012.  Dissecting neural function using targeted genome engineering technologies. ACS Chem Neurosci. 3(8):603-10. Google Scholar PubMed