Circuits in cell biology and circuits in electronics may be viewed as being highly similar with biology using molecules, ions, proteins, and DNA rather than electrons and transistors. This project exploits the astoundingly detailed similarity between the equations of chemistry and the equations of subthreshold analog electronics to attempt to create large-scale nonlinear dynamical systems that mimic the sensing, actuation, and control systems of biological cells at ultra-fast time scales including their stochastic properties. This project has applications in both systems biology, which aims at an engineering understanding of molecular networks within the cell and in synthetic biology, where it can help solve several bottlenecks in its design, analysis, robustness, and scalability via rigorous analog circuit techniques. Work in this project involves the design and testing of molecular circuits in bacteria and yeast, the design and testing of analog microelectronic chips useful for ultra-fast simulations of molecular and cellular systems, and the creation of analog circuit models of molecular networks.
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