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Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations.
/0 Comments/in Publications /by syn-adminSpiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: mechanistic studies with 18O.
/0 Comments/in Publications /by syn-adminNiles JC, Wishnok JS, Tannenbaum SR. 2004. Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: mechanistic studies with 18O. Chem Res Toxicol. 17(11):1510-9. Google Scholar PubMed
Spirodihydantoin is a minor product of 5-hydroxyisourate in urate oxidation.
/0 Comments/in Publications /by syn-adminYu H, Niles JC, Wishnok JS, Tannenbaum SR. 2004. Spirodihydantoin is a minor product of 5-hydroxyisourate in urate oxidation. Org Lett. 6(19):3417-20. Google Scholar PubMed
A novel nitroimidazole compound formed during the reaction of peroxynitrite with 2′,3′,5′-tri-O-acetyl-guanosine.
/0 Comments/in Publications /by syn-adminNiles JC, Wishnok JS, Tannenbaum SR. 2001. A novel nitroimidazole compound formed during the reaction of peroxynitrite with 2′,3′,5′-tri-O-acetyl-guanosine. J Am Chem Soc. 123(49):12147-51. Google Scholar PubMed
Spiroiminodihydantoin is the major product of the 8-oxo-7,8-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue.
/0 Comments/in Publications /by syn-adminNiles JC, Wishnok JS, Tannenbaum SR. 2001. Spiroiminodihydantoin is the major product of the 8-oxo-7,8-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue. Org Lett. 3(7):963-6. Google Scholar PubMed
The chemistry of DNA damage from nitric oxide and peroxynitrite.
/0 Comments/in Publications /by syn-adminBurney S, Caulfield JL, Niles JC, Wishnok JS, Tannenbaum SR. 1999. The chemistry of DNA damage from nitric oxide and peroxynitrite. Mutat Res. 424(1-2):37-49. Google Scholar PubMed