Posts

A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.

Aakre CD, Phung TN, Huang D, Laub MT.  2013.  A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp. Mol Cell. 52(5):617-28. Google Scholar PubMed

Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.

Ashenberg O, Keating AE, Laub MT.  2013.  Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans. J Mol Biol. 425(7):1198-209. Google Scholar PubMed

Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.

Capra EJ, Perchuk BS, Skerker JM, Laub MT.  2012.  Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families. Cell. 150(1):222-32. Google Scholar PubMed

Crystal structure of the channelrhodopsin light-gated cation channel.

Kato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S et al.  2012.  Crystal structure of the channelrhodopsin light-gated cation channel. Nature. 482(7385):369-74. Google Scholar PubMed

Precise manipulation of chromosomes in vivo enables genome-wide codon replacement.

Isaacs FJ, Carr PA, Wang HH, Lajoie MJ, Sterling B, Kraal L, Tolonen AC, Gianoulis TA, Goodman DB, Reppas NB et al.  2011.  Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science. 333(6040):348-53. Google Scholar PubMed

A DNA damage checkpoint in Caulobacter crescentus inhibits cell division through a direct interaction with FtsW.

Modell JW, Hopkins AC, Laub MT.  2011.  A DNA damage checkpoint in Caulobacter crescentus inhibits cell division through a direct interaction with FtsW. Genes Dev. 25(12):1328-43. Google Scholar PubMed

A dynamic complex of signaling proteins uses polar localization to regulate cell-fate asymmetry in Caulobacter crescentus.

Tsokos CG, Perchuk BS, Laub MT.  2011.  A dynamic complex of signaling proteins uses polar localization to regulate cell-fate asymmetry in Caulobacter crescentus. Dev Cell. 20(3):329-41. Google Scholar PubMed

Evolving a robust signal transduction pathway from weak cross-talk.

Siryaporn A, Perchuk BS, Laub MT, Goulian M.  2010.  Evolving a robust signal transduction pathway from weak cross-talk. Mol Syst Biol. 6:452. Google Scholar PubMed

Structural instability of plasmid biopharmaceuticals: challenges and implications.

Oliveira PH, Prather KJones, Prazeres DMF, Monteiro GA.  2009.  Structural instability of plasmid biopharmaceuticals: challenges and implications. Trends Biotechnol. 27(9):503-11. Google Scholar PubMed

Cloning and characterization of uronate dehydrogenases from two pseudomonads and Agrobacterium tumefaciens strain C58.

Yoon S-H, Moon TSeok, Iranpour P, Lanza AM, Prather KJones.  2009.  Cloning and characterization of uronate dehydrogenases from two pseudomonads and Agrobacterium tumefaciens strain C58. J Bacteriol. 191(5):1565-73. Google Scholar PubMed