Posts

Crystal structure of Cas9 in complex with guide RNA and target DNA.

Nishimasu H, F Ran A, Hsu PD, Konermann S, Shehata SI, Dohmae N, Ishitani R, Zhang F, Nureki O.  2014.  Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell. 156(5):935-49. Google Scholar PubMed

Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling.

Podgornaia AI, Casino P, Marina A, Laub MT.  2013.  Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling. Structure. 21(9):1636-47. Google Scholar PubMed

Synthetic circuits integrating logic and memory in living cells.

Siuti P, Yazbek J, Lu TK.  2013.  Synthetic circuits integrating logic and memory in living cells. Nat Biotechnol. 31(5):448-52. Google Scholar PubMed

Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.

Ashenberg O, Keating AE, Laub MT.  2013.  Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans. J Mol Biol. 425(7):1198-209. Google Scholar PubMed

Using analyses of amino Acid coevolution to understand protein structure and function.

Ashenberg O, Laub MT.  2013.  Using analyses of amino Acid coevolution to understand protein structure and function. Methods Enzymol. 523:191-212. Google Scholar PubMed

Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity.

Capra EJ, Perchuk BS, Ashenberg O, Seid CA, Snow HR, Skerker JM, Laub MT.  2012.  Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity. Mol Microbiol. 86(6):1393-403. Google Scholar PubMed

Dissecting neural function using targeted genome engineering technologies.

Hsu PD, Zhang F.  2012.  Dissecting neural function using targeted genome engineering technologies. ACS Chem Neurosci. 3(8):603-10. Google Scholar PubMed

Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains.

Cong L, Zhou R, Kuo Y-C, Cunniff M, Zhang F.  2012.  Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat Commun. 3:968. Google Scholar PubMed

Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.

Capra EJ, Perchuk BS, Skerker JM, Laub MT.  2012.  Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families. Cell. 150(1):222-32. Google Scholar PubMed

Crystal structure of the channelrhodopsin light-gated cation channel.

Kato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S et al.  2012.  Crystal structure of the channelrhodopsin light-gated cation channel. Nature. 482(7385):369-74. Google Scholar PubMed