Crystal structure of Cas9 in complex with guide RNA and target DNA.
. 2014. Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell. 156(5):935-49. Google Scholar PubMed
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Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling.
/0 Comments/in Publications /by syn-adminPodgornaia AI, Casino P, Marina A, Laub MT. 2013. Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling. Structure. 21(9):1636-47. Google Scholar PubMed
Synthetic circuits integrating logic and memory in living cells.
/0 Comments/in Publications /by syn-adminSiuti P, Yazbek J, Lu TK. 2013. Synthetic circuits integrating logic and memory in living cells. Nat Biotechnol. 31(5):448-52. Google Scholar PubMed
Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.
/0 Comments/in Publications /by syn-adminAshenberg O, Keating AE, Laub MT. 2013. Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans. J Mol Biol. 425(7):1198-209. Google Scholar PubMed
Using analyses of amino Acid coevolution to understand protein structure and function.
/0 Comments/in Publications /by syn-adminAshenberg O, Laub MT. 2013. Using analyses of amino Acid coevolution to understand protein structure and function. Methods Enzymol. 523:191-212. Google Scholar PubMed
Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity.
/0 Comments/in Publications /by syn-adminCapra EJ, Perchuk BS, Ashenberg O, Seid CA, Snow HR, Skerker JM, Laub MT. 2012. Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity. Mol Microbiol. 86(6):1393-403. Google Scholar PubMed
Dissecting neural function using targeted genome engineering technologies.
/0 Comments/in Publications /by syn-adminHsu PD, Zhang F. 2012. Dissecting neural function using targeted genome engineering technologies. ACS Chem Neurosci. 3(8):603-10. Google Scholar PubMed
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains.
/0 Comments/in Publications /by syn-adminCong L, Zhou R, Kuo Y-C, Cunniff M, Zhang F. 2012. Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat Commun. 3:968. Google Scholar PubMed
Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.
/0 Comments/in Publications /by syn-adminCapra EJ, Perchuk BS, Skerker JM, Laub MT. 2012. Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families. Cell. 150(1):222-32. Google Scholar PubMed
Crystal structure of the channelrhodopsin light-gated cation channel.
/0 Comments/in Publications /by syn-adminKato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S et al. 2012. Crystal structure of the channelrhodopsin light-gated cation channel. Nature. 482(7385):369-74. Google Scholar PubMed
