Posts

Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells.

Nissim L, Perli SD, Fridkin A, Perez-Pinera P, Lu TK.  2014.  Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells. Mol Cell. 54(4):698-710. Google Scholar PubMed

Analog synthetic biology.

Sarpeshkar R.  2014.  Analog synthetic biology. Philos Trans A Math Phys Eng Sci. 372(2012):20130110. Google Scholar  PubMed

Genome-scale CRISPR-Cas9 knockout screening in human cells.

Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelsen TS, Heckl D, Ebert BL, Root DE, Doench JG et al.  2014.  Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 343(6166):84-7. Google Scholar PubMed

Optical control of mammalian endogenous transcription and epigenetic states.

Konermann S, Brigham MD, Trevino AE, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F.  2013.  Optical control of mammalian endogenous transcription and epigenetic states. Nature. 500(7463):472-6. Google Scholar PubMed. Google Scholar PubMed

Retroactivity controls the temporal dynamics of gene transcription.

Jayanthi S, Nilgiriwala KSoli, Del Vecchio D.  2013.  Retroactivity controls the temporal dynamics of gene transcription. ACS Synth Biol. 2(8):431-41. Google Scholar PubMed

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.

Bikard D, Jiang W, Samai P, Hochschild A, Zhang F, Marraffini LA.  2013.  Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res. 41(15):7429-37. Google Scholar PubMed

Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.

Capra EJ, Perchuk BS, Skerker JM, Laub MT.  2012.  Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families. Cell. 150(1):222-32. Google Scholar PubMed