Researchers engineer new mouse model to study disease

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Time-saving tool takes advantage of CRISPR gene-editing technology

“The ‘Cas9 mouse’ allows researchers to more easily perturb multiple genes in vivo,” says Zhang, who, along with Sharp, served as co-senior author of the Cell paper. “The goal in developing the mouse was to empower researchers so that they can more rapidly screen through the long list of genes that have been implicated in disease and normal biological processes.”

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