An easier way to manipulate malaria genes

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New approach to knocking out parasite’s genes could make it easier to identify drug targets.

“Even though we’ve sequenced the entire genome of Plasmodium falciparum, half of it still remains functionally uncharacterized. That’s about 2,500 genes that if only we knew what they did, we could think about novel therapeutics, whether it’s drugs or vaccines,” says Niles, the senior author of a paper describing the technique in the Aug. 10 online edition of Nature Methods.

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