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Rahul Sarpeshkar profiled on MIT News

"Rahul Sarpeshkar bridges biology and engineering to advance research and applications in biotechnology, medicine, and supercomputing."

Recent Publications

Church GM, Elowitz MB, Smolke CD, Voigt CA, Weiss R. Realizing the potential of synthetic biology. Nat Rev Mol Cell Biol. 2014;15(4):289-94.
Lee MN, Ye C, Villani A-, Raj T, Li W, Eisenhaure TM, et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science. 2014;343(6175):1246980.
Simcikova M, Prather KL, Prazeres DM, Monteiro GA. On the dual effect of glucose during production of pBAD/AraC-based minicircles. Vaccine. 2014;32(24):2843-6.
Nishimasu H, Ran AF, Hsu PD, Konermann S, Shehata SI, Dohmae N, et al. Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell. 2014;156(5):935-49.
Gyorgy A, Del Vecchio D. Modular composition of gene transcription networks. PLoS Comput Biol. 2014;10(3):e1003486.
Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelsen TS, et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 2014;343(6166):84-7.

About the Synthetic Biology Center

The goal of synthetic biology is to make the construction of novel biological systems into a practical and useful engineering discipline.

The key to that is development of an engineering methodology based on standardized and well-characterized interchangeable parts. Biological systems can be a basis for practical programmable materials, providing an engineering substrate with exquisite control over and response to the chemical world.

The range of potential applications is vast, encompassing but not limited to: diagnostics, therapeutics, sensors, environmental remediation, energy production, and a host of other biomolecular and chemical manufacturing outputs. Synthetic biology can also help us gain valuable insight into fundamental biological principles and improve our quantitative understanding of the living world.

The mission of the Synthetic Biology Center at MIT is to develop and advance the engineering discipline for this emerging field. Read more >